Delta 8 binds to CB1 receptors in the nervous system and has the ability to offer unique potent effects on pain. The nervous system consists of a series of pain receptors attached to the body’s nerve endings, that detects pain and transmits pain signals to the brain to let it know it has been injured. Cannabinoid receptors in the nervous system are responsible for regulating the sensitivity of the pain receptors.
Among hundreds of cannabinoids, delta-8-tetrahydrocannabinol, or delta-8-THC, has rapidly gained popularity among cannabis product consumers. Delta-8-THC is an isomer or a chemical analog of delta-9-THC, which is the molecule that causes a ‘’high’’ when Cannabis is consumed. No Cap Hemp Co THCO products differs from delta-9-THC in its molecular structure by having a double bond between carbon atoms 8 and 9 rather than carbon atoms 9 and 10. Reggio (1987), discovered that Delta-8-THC has a lower affinity for the CB1 receptor and thus a lower psychotropic potency than delta-9-THC due to its altered structure Delta-8-THC is naturally present in Cannabis, though in much lower concentrations than delta-9-THC. It can also be made from other cannabinoids through chemical synthesis in laboratories.
Are Delta-8-THC Gummies Good for Pain?
In states where medical Cannabis is legal, pain, particularly chronic pain, is considered a qualifying condition. According to Weber et al (2010), low to moderate doses of Delta-9-THC may effectively treat neuropathic pain, which is often debilitating and difficult to manage. According to the same study, nearly a quarter of patients could not benefit from Delta-9 due to various side effects of the psychoactivity, such as paranoia and anxiety. This is where Delta-8-THC comes into play. If Delta-8 has similar analgesic effects, it may have a far less psychoactive impact and fewer side effects. on the anti-nausea effects of Delta-8, Standish (2016), discovered that it might be more effective than Delta-9 for pediatric use because it was far less likely to cause negative side effects, even at higher doses. What does the research say about Delta-8-THC as a pain reliever?
We don’t know much yet, but a few studies are available to help us understand Delta-8’s potential. According to Toguri et al (2016), Delta-8-THC’s interaction with the CB1 receptor (the Endocannabinoid System’s central nervous system portion) allowed it to mediate pain and inflammation. Delta-8 was overwhelmingly effective in alleviating pain and inflammation caused by corneal injuries in mice. In spite of the lack of studies on Delta-8-THC, scientists believe it may have many of the same therapeutic effects as Delta-9-THC because of its structural similarity. Analgesic properties of Delta-9-THC have been studied for years. The authors concluded that Delta-8 has promising pain-relieving effects that could be translated to human studies, but more research is required. The National Cancer Institute also recognizes Delta-8-THC as an “analog of tetrahydrocannabinol (THC) with antiemetic, anxiolytic, appetite-stimulating, analgesic, and neuroprotective properties. More research is needed to fully understand Delta-8-THC’s interaction with pain signaling in the body. Still, anecdotal reports suggest that Delta-8 is effective for pain management, and many people prefer it to Delta-9 due to its milder psychoactive effects.
Dosing On Delta-8-THC Gummies
The appropriate CBD Gummy Bears dosage depends on product strength (number of milligrams) and delta 8 THC strength per milligram. Products vary in strength and volume. Examples of 30 mL and 60 mL bottles of delta 8 THC tinctures are available. The same goes for gummies, vapes, and other delta-8-THC products. You want to know how much delta 8 THC is in a single serving. Companies label their products with recommendations so new users can easily estimate how much delta 8 THC they need to obtain desired results. The potency of delta 8 THC in liquid items like tinctures and vape cartridges is measured in mg/mL. For example, 30 ml delta 8 THC tincture has 1200 mg. So, 1 mL of this tincture has about 40 mg of delta 8. Even experienced cannabis users can get cognitive benefits at a quarter of a dropper of delta 8 THC. Solid items like candies and pills already include a premeasured amount of delta 8 THC; therefore, no measuring is required. You consume enough capsules or gummies to match your dosing requirements.
Choosing Delta-8-THC Gummies
Delta 8 edibles, such as gummies and cookies, and capsules function almost identically, with the delta-8 compound passing through the digestive system before being released into the bloodstream. Many patients suffering from chronic pain prefer edibles, particularly gummies, because of the long-lasting effects; additionally, they lack an earthy taste, which may be a turn-off for some people. This delivery method has the longest duration of all, with effects lasting an average of 8 hours and sometimes longer. The effects may take up to two hours, but many users who prefer edibles will attest to its long-lasting analgesic effects.
Can One Overdose On Delta-8-THC Gummies
Cannabinoids don’t interact with the brain stem area that controls breathing; thus, one can’t overdose on them. To cause liver poisoning, you need to inject 50 grams of pure THC, which is rare. In addition, Cannabis and its related constituents are not injectable making them hard to overdose on. However, too much delta 8 THC can make one feel nauseous, feel tired, disoriented, and confused, but not as much as with delta 9 THC. Anxiety and paranoia are uncommon in delta 8 THC users. You can also expect normal cannabis side effects, including dry lips, burning eyes, and a high appetite. Various studies claim that delta 8 THC produces a high of up to 70% of that of delta-9-THC. Most delta-8 users describe its effects as body-focused, with an enhanced mood and alleviation from physical discomforts like pain, nausea, and vomiting. Delta 8 THC has dose-dependent effects. Low doses can boost energy, while high quantities are sedating and leave you couch-locked.
Delta 8 THC is a unique cannabinoid found in hemp that shares many properties with CBD Oil UK but has a unique way of providing pain relief due to its affinity for nervous system receptors. Delta 8, like cannabidiol, is available in various delivery methods, each of which can produce the desired results in its unique way. If you choose to take delta 8 for pain treatment, you should first visit a physician who is familiar with the unique nature of your pain issue and is sensitive to your individual needs. It is also advisable to purchase a delta-8 product with a milligram strength that reflects the severity of your situation, as delta8, like CBD, varies in milligram strength.
Hively, R. L., Mosher, W. A., & Hoffmann, F. W. (1966). Isolation of
trans-Δ6-tetrahydrocannabinol from marijuana. Journal of the American Chemical Society, 88(8), 1832-1833.
Kruger, J. S., & Kruger, D. J. (2022). Delta-8-THC: Delta-9-THC’s nicer younger
sibling?. Journal of cannabis research, 4(1), 1-8.
Reggio, P. H. (1987). Cannabinoid Activity: Refinement of. Structure-activity
Relationships of the Cannabinoids, 87(1534), 82.
Standish, N. D. (2016). Cannabis in Palliative and Hospice Medicine.
Toguri, J. T., Caldwell, M., & Kelly, M. E. (2016). Turning down the thermostat:
modulating the endocannabinoid system in ocular inflammation and pain. Frontiers in Pharmacology, 7, 304.
Weber, J., Schley, M., Casutt, M., Gerber, H., Schuepfer, G., Rukwied, R., … & Konrad,
C. (2010). Tetrahydrocannabinol (Delta 9-THC) treatment in chronic central neuropathic pain and fibromyalgia patients: results of a multicenter survey. Anesthesiology research and practice, 2009.